How ICSI can help in infertility?

Intracytoplasmic Sperm Injection (ICSI):

Intracytoplasmic sperm injection (ICSI) is very analogous to conservative IVF in that gametes (eggs and sperm) are together from each partner. The dissimilarity between the two procedures is the process of achieving fertilization. The head of the sperm must connect to the outside of the egg before a man’s sperm can fertilize a woman’s egg. Once it is attached, the sperm pushes through the external layer to the within the egg (cytoplasm), where fertilization takes place. 

In some cases sperm cannot penetrate the outer layer such as the egg’s external layer may be broad or solid to go through or the sperm may be incapable to swim. In these cases, a process called intracytoplasmic sperm injection (ICSI) can be made along with in vitro fertilization (IVF) to assist fertilize the egg. During ICSI, a single sperm is infused unswervingly into the cytoplasm of the egg.

How does ICSI work?

By Vitro fertilization (IVF), an egg may be fertilized in two ways such as traditional and ICSI. In traditional IVF, 50,000 or more swimming sperm are located close to the egg in a laboratory dish. Fertilization happens when one of the sperm enters into the cytoplasm of the egg. In the ICSI process, a petite needle, called a micropipette, is used to insert a single sperm into the midpoint of the egg. Either through traditional IVF or ICSI method, once fertilization occurs, the fertilized egg grows in a laboratory for some days before it is transferred to the woman’s uterus (womb).

Why would I need ICSI?

Intracytoplasmic sperm injection (ICSI) helps to conquer fertility tribulations, such as:

• The male partner constructs little sperm to do non-natural insemination.
• Sperm cannot stir in a normal way.
• The sperm may have a problem attaching to the egg.
• In vitro developed eggs are being used.
• Formerly frozen eggs are being used.

Troubles Occur During or after the ICSI process:

Intracytoplasmic sperm injection (ICSI) fertilizes 50% to 80% of eggs. But the subsequent troubles may occur during or after this process such as a few or all of the eggs may be spoiled or the egg might not grow into an embryo even after it is inserted with sperm or the embryo may discontinue growing.

Conclusion

However some of the doctors consider that ICSI escorts to labor defects, but it may also result due to the intrinsic peril of abnormalities in parents undergoing this process. If any person is looking to endure the ICSI process one can consult with his/her doctor first. 

Care Womens Centre is the best fertility centre in Indore, also called test tube baby center. This center is the lowest cost IVF center in Indore. Care Womens Centre provides IVF, IUI, ICSI, Egg / Sperm / Embryo Donor, Cryopreservation / Sperm / Embryo Freezing, Laparoscopy & Hysteroscopic, Ultrasound Scan  and other services. Dr Shweta Kaul Jha is one of the leading IVF specialists in Indore at Care Womens Centre , providing a wide variety of infertility treatments as well as in vitro related procedures such as IVF-ICSI, genetic testing, preserving fertility in cancer patients, and many more. Book an appointment today  call now us  +918889016663 and visit https://www.carewomenscentre.com/ for more information.

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To More Post:-  Advantage and Disadvantage of ICSI

Advantage and Disadvantage of ICSI

As we know that, ICSI or Intracytoplasmic Sperm Injection is a form of IVF (in vitro fertilization) that is most frequently used in cases of tremendous male infertility, after oocyte conservation or after recurring breakdown with the conservative IVF attempts. In the case of usual IVF, numerous sperms are placed with an egg collectively. Contradiction to that, the Intracytoplasmic Sperm Injection process involves the embryologist taking a single sperm and injecting unswervingly into an egg.

Advantages of ICSI:

ICSI or Intracytoplasmic Sperm Injection is the fortunate thing to the couples who are not able to conceive naturally. 

There are many circumstances where the treatment is helpful.

• In case, where a man expostulate does not hold sperm regardless of their production

• ICSI aids couples getting pregnant in circumstances in the vein of low sperm count, the nonstandard form of sperm, poor motility of sperm, and physical obstruction.

• If fertilization is not achieved by IVF (in vitro fertilization), ICSI is used in the next IVF cycle to improve the probability of fertilization. It also aids if you wish for pregnancy post-vasectomy.

• At times frozen sperms do not emerge active or the eggs become hard by freezing. ICSI is a great alternative to defeat these complications.

• In the case of Pre-implementation Genetic Diagnosis (PGD) with IVF, to hereditarily screen embryos, sperms that have not fertilized the egg also enclose the embryo. This can result in imprecise results of the Pre-implementation Genetic Diagnosis. ICSI ensures that non-participating sperms do not pressure the diagnosis.

• If during IVF, eggs are retrieved from the ovaries and their last maturation stage is completed in the laboratory, ICSI significantly improves the rate of fertilization.

Disadvantages of ICSI:

Intracytoplasmic Sperm Injection is considered a low-risk treatment. Even though it is a superior process, it is also connected with some drawbacks and risks.

Embryo spoil: There are possibilities that an egg does not end up into a vigorous embryo after fertilization. Some eggs and embryos can get damaged throughout the process.

Pregnancy with multiples: If ICSI is used by the side of IVF, there will be a high chance of conceiving twins or triplets. Mothers pregnant with multiples often face difficulties in pregnancy and childbirth.

Birth imperfection: The chances of birth defects are somewhat higher in ICSI as compared to the usual pregnancy. Conversely, these issues are exceptional.

Conclusion:

If you have any problem/difficulty, then you should consult your doctor, whose experience in the field and matter will shed some light on the substance.

Care Womens Centre is a  leading one of the Best fertility hospitals and IVF centers in Indore. We provides IVF, IUI, ICSI and infertility treatment in Indore at very affordable cost. Care Womens Centre is famous all over the India for its work. Dr. Shweta Call Jha is the best IVF Specialist  in Indore at Care Womens Centre. If you are looking for the Best centre for IVF in Indore for a long time then contact Care Women's Centre. Book an appointment call now 8889016663 and visit https://www.carewomenscentre.com/ for more information.

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To More Post:-  FACTORS AFFECTING MALE FERTILITY

FACTORS AFFECTING MALE FERTILITY

According to Indian Society of Assisted Reproduction, 10 to 14 percent of couples in India are not able to conceive a child naturally. Out of which 50 percent cases are due to Male Infertility. This is typically due to sexual abnormalities in male body. A man's semen quality plays a vital role for conceiving a baby in female. There can be many reasons behind male infertility like low production of sperm, abnormal sperm function and certain blockages that cause hindrance in the delivery of sperm. There are 3 major properties of male sperm: -

1. Sperm should be enough in count.

2. Testicles should produce healthy sperm.

3. Sperm should be motile enough.

Male Infertility can be irritating and stressful for many couples. There are certain factors that affect male fertility, let's see them one by one: -

INDUSTRIAL CHEMICALS AND METALS

Prolonged exposure to chemicals like benzenes, toluene, pesticides, xylenes, herbicides, painting materials and organic solvents may lead to low sperm counts. Exposure to heavy metals like lead may also become reason for male infertility.

RADIATION TO X-RAYS

Does your work include exposing X-rays for longer times? Then you should be careful because it can have permanent negative effects on your semen quality and production.  

OVERHEATING OF THE TESTICALS

Elevated temperatures are responsible for heating testicles which may become responsible for sperm impairment. Though there's no scientific research data to back up this argument. Sitting for longer duration, wearing tight clothes may also increase the heat in scrotum area and slightly reduce the sperm production.  

SMOKING OR CONSUMING TOBACCO

It has been observed that men who smoke or chew tobacco are reported to have a lower sperm count than those who don't do any of those two. Inhaling secondhand smoke can also do the same fertility damage.

ALCOHOL CONSUMPTION

It's time to put halt on your alcohol consumption, as it can lower your testosterone levels for a healthy sex life. High alcohol consumption can cause erectile dysfunction and lowers the sperm production in scrotum. Liver disease caused by binge drinking may also infertility problems in male.

DEPRESSION AND EMOTIONAL STRESS

Emotional Stress releases cortisol hormone in the body which interferes with sexual processes causing low libido and sperm count. If you’re suffering from depression, you might experience low sexual energy and delayed or premature ejaculation.  

OVERWEIGHT OF THE BODY

Obesity can affect the quality of sperm by impacting the sperm count. Therefore, it becomes super important to keep body fit, active and in-shape.

OVERDOING DRUG ABUSE

Anabolic steroids are taken by body building athletes to increase muscle strength and growth. These same drugs later-on become responsible for shrinking of the testicles which leads to decline in sperm production. Use of recreational drugs like marijuana or cocaine also temporarily reduce the number and quality of sperm. 

These were some factors that affect the male fertility. All of these can be avoided by taking preventions, avoiding addictive substances and eating healthy diet.

If you’re a couple facing fertility issues, then contact Care Womens Centre. It’s the best IVF center in Indore with an experienced faculty.

Care Womens Centre is a leading  one of the best IVF centers and Best fertility hospitals in Indore. Which is also known as Test Tube Baby Center in Indore who provides high success rate infertility treatment in indore at affordable cost. its famous Best centre for IVF in Indore. If you are looking for the best low IVF treatment cost hospital in Indore, contaect to Care Womens Centre. Book an appointment call now 8889016663 and visit https://www.carewomenscentre.com/ for more information.

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To More Post:-  Facts about and Medical Definition of Endometriosis

Facts about and Medical Definition of Endometriosis

Endometriosis is a common disorder of the female reproductive organs and is the leading cause of chronic pelvic pain in women.

1. In women who have endometriosis, tissue similar to the lining of the uterus (endometrium) develops in other areas of the body, most commonly within the pelvic area or the abdominal cavity. The endometrial tissue may attach itself to the ovaries, the outside of the uterus, the intestines, or other abdominal organs. Rarely, endometriosis occurs outside the abdominal cavity, such as in the brain or lungs. Endometriosis may also develop in surgical scars following surgery on pelvic organs. The term "implant" is used to refer to a specific area of endometriosis in a certain tissue.
2. Endometriosis may not produce specific symptoms and signs, and most women with the condition don't have any. However, women who have endometriosis and experience symptoms and signs they may include:

• Pelvic pain that worsens just before a woman's period (menstruation).
• Pelvic pain that increases during menstration and gets better when her period ends.
• Pain during sexual intercourse
• Infertility

1. Many American women will experience problems with endometriosis, but an exact determination of the number of women affected is difficult, since many women may have the condition and do not have symptoms. In other situations, women may also have symptoms that could be attributed to endometriosis, but never undergo formal diagnostic studies to confirm that the condition is present. Most women who are diagnosed with endometriosis are between 25 and 35 years of age. Women may have symptoms for years before a definitive diagnosis is made.
2. During pelvic surgery for any gynecologic condition, about 1% of women are observed to have endometriosis. The percentages are much higher in young women undergoing laparoscopic surgery for pelvic pain and in women undergoing laparoscopic surgery to evaluate infertility.
3. Endometriosis is more common in Caucasian women than in African American or Asian women. Studies have also reported that endometriosis tends to occur most commonly in taller, thin women with a low body mass index (BMI).
4. Women with first-degree relatives who have endometriosis are also more likely to develop the condition, suggesting that the genes a woman inherits from her parents can sometimes predispose her to develop endometriosis.

Are you looking for the best Fertility centre and Test tube baby center in Indore? if yes so Care Womens Centre is a leading one of the best Test tube baby center and Best fertility hospitals in Indore. Dr Shweta Kaul Jha is one of the best IVF specialists in Indore at Care Womens Centre, that provide the  80% successful  infertility treatment in Indore. She is also one of the eminent and renowned doctors in the field of gynecology and infertility treatments. She is one of the first infertility specialists of the city who had full-fledged structured training to understand and treat reproductive medicine which includes reproductive endocrinology, endoscopic treatment and IVF/ICSI treatments. Book an appointment call now 8889016663 and visit https://www.carewomenscentre.com/ for more information.

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To More Post:-  When to See a Fertility Specialist

When to See a Fertility Specialist

A fertility specialist is usually an obstetrician-gynecologist (specialist in women's reproductive health) with advanced education, research, and professional skills in reproductive endocrinology. These highly trained and qualified doctors are the specialists to see about infertility.

Couples may want to talk to a health care professional for a referral to a clinic where doctors and staff have this special training. In addition, fertility clinics often have specialized equipment and imaging technology needed to make a diagnosis and to do semen testing and other specialized tests right at the office.

Check the American Society for Reproductive Medicine for a specialist and clinic in your area. A primary care physician or gynecologist will also be able to refer you to a fertility clinic.

Infertility is a problem that involves both partners. Therefore, the infertility specialist evaluates both the woman and the man. Testing for infertility is usually not done until after the couple has tried to become pregnant for at least 1 year if the woman is younger than 35 years, or older than 35 years and have not conceived during a six-month period of trying.

How Is Infertility Diagnosed?

Medical history

A health care professional will take a complete medical history. Couples may be asked to provide the following information:

• Complete medical history for both the man and the woman
• Whether the woman has never been pregnant (primary infertility) or has been pregnant and is now unable to conceive (secondary infertility)
• How long has the couple been trying to become pregnant
• History of the woman's previous pregnancies, if any
• How often the couple has intercourse
• A woman's menstrual history
• Current medical treatment for the man and woman

Physical examination

A health care professional may perform a physical examination on both partners, including the following aspects:

• Routine blood pressure, pulse, and temperature
• Height and weight
• Inspection of sexual organs
• Hormone testing
• Woman: Pelvic ultrasound scan to look for masses, cervical mucus testing
• Man: Genital examination, testicle size, hernias

A health care professional will discuss the findings from the medical history and physical examination. Sometimes, a complete infertility evaluation may take up to two menstrual cycles before the factors causing the infertility can be found.

Further testing for men

The male partner will be asked to submit a semen sample for a complete semen analysis. Even though a man has fathered a child in the past, he will still be asked to submit a semen sample because his reproductive system may have changed.

The semen sample may be collected at the laboratory (in a private room through masturbation). If a sample is collected at home, it must be collected in a sterile plastic container and delivered to the lab at a body temperature no more than 60 minutes after ejaculation.

Some men cannot produce a semen sample through masturbation. Therefore, the sample can be collected through intercourse, using a special non-spermicidal condom provided by the laboratory. For best results, the semen sample should be collected 3 to 5 days after a period of having no sexual intercourse.

A man may produce no sperm for various reasons. He may produce few sperm or sperm that have defects that prevent them from reaching or fertilizing the egg.

Further testing for women

Several conditions may affect a woman's ability to get pregnant. A health care professional will evaluate the entire reproductive system.

The cervix plays a key role in the transport of the sperm after intercourse. Cervical mucus production, amount, and characteristics change according to the estrogen concentration depending on the menstrual cycle.

The uterus is the final destination for the embryo and the place where the fetus develops until delivery. Therefore, the uterus may be associated with primary infertility or with pregnancy problems and premature delivery. Other problems affect the development and function of the uterus (specifically the endometrium or inner layer of the uterus).

Ovaries may not release eggs. Fallopian tubes may be blocked. The doctor will want to evaluate all parts of the reproductive system.

The health care professional may use any of several procedures to examine the woman's reproductive organs:

Pelvic exam: This is a general physical examination in which the doctor feels the uterus for detectable masses and views the cervix.

Hysterosalpingogram: This is an imaging study of the uterus and Fallopian tubes after contrast dye has been injected through the cervix. It shows the shape of the uterus and if the Fallopian tubes are open. The dye appears white on an X-ray. This test is usually performed before ovulation so the dye does not disrupt an egg or developing embryo. The woman may be given pain medication before the test because some women experience minor pain.

Ultrasound: Pelvic ultrasound has become an important tool in the evaluation and monitoring of infertile women. It is a way to detect uterine fibroids, endometrial polyps, ovarian cysts, and other abnormalities in the pelvis from the outside with sound waves. A sonohystogram, or saline infusion sonography (SIS) is a test that combines ultrasound with saline solution injected into the uterus.

Magnetic resonance imaging (MRI): This is another imaging procedure similar to an X-ray that uses magnetic waves to create images of the internal organs.

Hysteroscopy: This is a method of directly seeing the interior of the uterus with an instrument.

Laparoscopy: This is a surgical procedure that allows the doctor to see directly inside the pelvis with tiny instruments inserted through small cuts in the abdomen.

Endometrial biopsy: This test involves removal of a small piece of tissue from the uterine lining by a catheter inserted through the cervix. This test can help determine whether the menstrual cycle is normal and whether ovulation has occurred.

Infertility may be caused by so many different problems that it is beyond the scope of this discussion to outline them all.

Care Womens Centre is one of the best fertility centres in Indore. We are specialist in providing infertility treatment in Indore through the revolutionary method IVF. Our center is known for its world best treatment and the affordable cost of the treatment that makes the infertility treatment accessible for everyone. Dr Shweta Kaul Jha is a renowned reproductive IVF specialist in Indore at Care Womens Centre. We are providing the best treatments with the top- notched techniques and the latest methods used for IVF such as egg donation, sperm donation, IUI, test tube baby treatment Blastocyst techniques that maximize the success rates by many folds. Book an appointment call now  8889016663 and visit  https://www.carewomenscentre.com/ for more information.

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To More Post: Facts About Infertility

Facts About Infertility

Infertility is the inability of a couple to become pregnant (regardless of cause) after 1 year of unprotected sexual intercourse (using no birth control methods).

• Infertility affects men and women equally.

• Most infertility cases are treated with medication or surgery.

• Improvements in fertility treatment have made it possible for many women whose male partner is infertile to become pregnant. These new and advanced technologies include in vitro fertilization (IVF), intracytoplasmic sperm injection (ICSI), and other similar procedures.

What Causes Infertility?

The normal reproduction process requires interaction between the female and male reproductive tracts. The woman ovulates and releases an egg from her ovaries to travel through the Fallopian tube to her uterus (womb). The male produces sperm. Both egg and sperm normally meet in the woman's Fallopian tube, where fertilization occurs. The embryo then implants in the uterus for further development.

Infertility occurs when something in this pattern does not happen. The problem could be with the woman (female infertility), with the man (male infertility), or with both. Unknown factors cause infertility 10% of the time. For infertility with an unknown cause, all findings from standard tests may be normal. The actual cause of infertility may not be detected because the problem may be with the egg or sperm itself or with the embryo and its inability to implant.

Pelvic inflammatory disease (PID)

Sexually transmitted diseases, namely, gonorrhea and Chlamydia, may be associated with pelvic inflammatory disease (PID) and damage a woman's Fallopian tubes. A health care professional can detect pelvic inflammatory disease using cultures or molecular biologic studies of vaginal discharge and blood testing for sexually transmitted diseases.

If a woman does not recall ever having pelvic inflammatory disease, her doctor may be able to see scarring or blockage of the tubes during a surgical procedure called laparoscopy. Tiny cameras and instruments are inserted through small cuts in the abdomen to allow the doctor to view the reproductive organs.

Endometriosis

Endometriosis affects women during their reproductive years and may contribute to infertility. It can cause pelvic pain and infertility. A woman may be at risk for developing it if she has a family history of the disease. With endometriosis, uterine lining tissue grows outside the uterus and may damage the ovaries and Fallopian tubes. A woman may not know she has a mild form of this condition. Sometimes the doctor finds it during laparoscopy.

Environmental and occupational factors

Certain environmental factors may cause men to produce a less concentrated sperm. Exposure to lead, other heavy metals, and pesticides have been associated with male infertility. Many other factors, such as excessive heat exposure, microwave radiation, ultrasound, and other health hazards, are more controversial as to whether they induce infertility.

Toxic effects related to tobacco, marijuana, and other drugs

Smoking may cause infertility in both men and women. In experimental animals, nicotine has been shown to block the production of sperm and decrease the size of a man's testicles. In women, tobacco changes the cervical mucus, thus affecting the way sperm reach the egg.

Marijuana may disrupt a woman's ovulation (release of the egg). Marijuana use affects men by decreasing the sperm count and the quality of the sperm.

Heroin, cocaine, and crack cocaine use induces similar effects but places the user at increased risk for pelvic inflammatory disease and HIV infection associated with risky sexual behavior.

In women, the effects of alcohol are related more to severe consequences for the fetus. Nevertheless, chronic alcoholism is related to disorders in ovulation and, therefore, interferes with fertility. Alcohol use by men interferes with the synthesis of testosterone and has an impact on sperm concentration. Alcoholism may delay a man's sexual response and may cause impotence (unable to have an erection).

Exercise

Exercise should be encouraged as part of normal activities. However, too much exercise is dangerous, especially for long-distance runners. For women, it may result in disruption of the ovulation cycle, cause no menstrual periods, or result in miscarriages (loss of pregnancy). In men, excessive exercise may cause a low sperm count.

Inadequate diet associated with extreme weight loss or gain

Obesity is becoming a major health issue in the United States. Obesity has an impact on infertility only when a woman's weight reaches extremes.

Weight loss with anorexia or bulimia can create problems with menstrual periods (no periods) and thyroid levels, thus disrupting normal ovulation.

Age

A woman becomes less fertile as she ages into her fifth decade of life (age 40-49 years). Among men, as they age, levels of testosterone fall, and the volume and concentration of sperm change.

Healthy couples younger than 30 years who have regular sexual intercourse and use no birth control methods have a 25% to 30% chance of achieving pregnancy each month. A woman's peak fertility is early in the third decade of life. As a woman ages beyond 35 years (and particularly after age 40 years), the likelihood of becoming pregnant is less than 10% per month.

Care Womens Centre is a one of the Best Fertility hospital and IVF center in Indore, where couples receive wholesome services for all types of fertility issues and high risk pregnancies. If you are looking for the Best centre for IVF in Indore come at Care Womens Centre. Book an appointment call now  8889016663 and visit  https://www.carewomenscentre.com/ for more information.

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To More Post: Decision analysis about the cost-effectiveness of different in vitro fertilization-embryo transfer protocol under considering governments, hospitals, and patient.

Decision analysis about the cost-effectiveness of different in vitro fertilization-embryo transfer protocol under considering governments, hospitals, and patient.

Abstract

OBJECTIVE:

The aim of this study was to explore the benefits of in vitro fertilization (IVF) for patients and hospitals under different protocols and if IVF treatment should be incorporated into health care.

PERSPECTIVE:

The government should consider including IVF treatment in health insurance. Hospitals and patients could obtain the best benefit by following the hospital's recommended protocol.

SETTING:

This retrospective study was conducted from January 2014 to August 2017 at an academic hospital.

METHODS:

A total of 7440 patients used gonadotropin-releasing hormone agonists (GnRHa) protocol, 2619 patients used, gonadotropin-releasing hormone antagonists (GnRHant) protocol, and 1514 patients used GnRHa ultra-long protocol. Primary outcomes were live birth rate (LBR), cost-effectiveness, hospital revenue, and government investment.

RESULTS:

The cycle times for the GnRHa protocol and the GnRHa ultra-long protocol were significantly higher than the GnRHant protocol. Patients who were ≤29 years chose the GnRHant protocol. The cost of a successful cycle was 67,579.39 ± 9,917.55 ¥ and LBR was 29.25%. Patients who were >30 years had the GnRHa protocol as the dominant strategy, as it was more effective at lower costs and higher LBR. When patients were >30 to ≤34 years, the cost of a successful cycle was 66,556.7 ± 8,448.08 ¥ and the LBR was 31.05%. When patients were >35 years, the cost of a successful cycle was 83,297.92 ± 10,918.05 ¥ and the LBR was 25.07%. The government reimbursement for a cycle ranged between 11,372.12 ± 2,147.71 ¥ and 12,753.67 ± 1,905.02 ¥.

CONCLUSIONS:

The government should consider including IVF treatment in health insurance. Hospitals recommend the GnRHant protocol for patients <29 years old and the GnRHa protocol for patients >30 years old, to obtain the best benefits. Patients could obtain the best benefit by using the protocol recommended by the hospital.

source: https://www.ncbi.nlm.nih.gov/pubmed/31083186

Care Womens Centre a is one of the Best IVF and Test tube baby center in Indore, And is one of the most revered and quality healthcare in India. We care deeply about our fertility community, and would like to help you build a beautiful family. Care Womens Centre provide the Best infertility treatment in Indore at affordable price. If you are search for the Best centre for IVF in Indore come to Care Womens Centre. Book an appointment Today call us now :- +918889016663 and visit  https://www.carewomenscentre.com/ for more information.

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To More Post: The infertility trap: how defeat and entrapment affect depressive symptoms.